The early changes of cerebral microcirculation after hypoxic-ischemic brain damage in newborn rats

Abstract

 Objective To observe the morphological changes of early microcirculation in the brain of newborn rats during hypoxic-ischemic brain injury. Methods In the animal model of hypoxic-ischemic brain injury, histochemical staining and brain tissue ink perfusion were used to observe brain tissue blood vessels Morphology and distribution. Results: Immediately after hypoxia-ischemia, the number of microvessels in the cerebral cortex, medulla, and hippocampus increased, the permeability of microvessels increased, thrombosis formed in microvessels, and hemorrhage occurred in many parts of the brain. At the same time, edema, loss of neurons, and glial cells occurred. Hyperplasia and a series of ischemic and hypoxic changes. Conclusion Cerebral microcirculation disorder exists in the early stage of hypoxic-ischemic brain injury, and attention should be paid to early correction during the treatment of clinical ischemic-hypoxic brain injury.