Clinical relationship between differentiation antigen presentation 7 and pediatric acute lymphoblastic leukemia

Abstract

To explore the clinical characteristics and treatment response of children with acute lymphoblastic leukemia (ALL) expressing CD7 antigen. Methods: Children who were hospitalized in Shanghai Children's Medical Center and the Second Affiliated Hospital of Guangzhou Medical College from 1998.4 to 2001.5 were selected. 82 patients with acute lymphoblastic leukemia (ALL) were studied. A set of CD series monoclonal antibodies were used to randomly detect the phenotype of children with ALL, and G-banding was used for karyotype analysis. The conventional chemotherapy regimen of Shanghai Children's Medical Center was used for treatment. CD7+ Compare with CD7- acute lymphoblastic lymphoma. Results: Compared with CD7- acute lymphoblastic lymphoma, CD7+ acute lymphoblastic lymphoma patients are older, have higher white blood cell count, significantly enlarged liver, more extramedullary leukemia and serious complications, and fewer people achieve CR in the first course of treatment. , it takes a long time to achieve CR, many people give up treatment or die within the first course of treatment, and the P170 rate is high (all P<0.05). Conclusion: CD7+ ALL has severe clinical symptoms, poor treatment response, and poor prognosis.
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